The 49ers were without three of their top playmakers for much of the matchup, with running back Christian McCaffrey (Achilles) and wide receivers Brandon Aiyuk (knee) and Deebo Samuel (illness) all sidelined by the end of the day. Their final touchdown, a sneak by Purdy, came with under two minutes to play.

The Chiefs, like the 49ers with Christian McCaffrey, have been missing their own starting running back all season. Isiah Pacheco had leg surgery in mid-September and could return six-to-eight weeks after that procedure. Kansas City is also missing wide receivers Hollywood Brown and Rashee Rice, the latter of whom had knee surgery last week.