Today, the mouse is by far the most common research mammal in the world. Initially, the focus was on the study of cancer, but the mouse is now used as a model by scientists of almost all biological ...

Selecting an appropriate mouse model is one of the most important decisions a pre-clinical researcher can make. Which is best suited for immuno-oncology? Cancer research and drug discovery has ...

the mouse has become the model of choice. Here the authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both ...

A new mouse model mimicking the liver symptoms of myotonic dystrophy type 1—the most prevalent form of adult-onset muscular dystrophy—provides insight into why patients develop fatty liver ...

Researchers from Congruence Therapeutics Inc. have described the development of a mouse model of genetic obesity with a clinically relevant, naturally occurring human melanocortin MC4 receptor (MC4R) ...

A well-characterized in vivo model of a1AT mutant Z liver injury, the PiZ mouse, is useful to better understand the pathways involved in this disease. The results of the referenced study show an ...