China-ASEAN Belt and Road Joint Laboratory on Mariculture Technology, Guangzhou, China ...

This work presents a valuable finding on how the interplay between transcription factors SOX2 and OCT4 establishes the pluripotency network in early mouse embryos. Despite the high quality of the data ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...

Calcineurin fine tunes the balance between proliferation and differentiation of Notch-responsive progenitors in the pancreatic ducts to enable beta cell regeneration in zebrafish.

This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the ...

Early-career researchers in the Global South have to overcome obstacles that are not found in high-income countries, but in Morocco at least, the future is looking brighter than the past.

This valuable study reports on a novel role of PD-1 in early T cell differentiation, showing that PD-1 stimulation impairs Th2 differentiation more effectively than that of Th1, with implications for ...

This study demonstrates that plant and fruit volatiles can be organized according to a low-dimensional hyperbolic map, and that within this map exist trajectories that correspond to important ...

A bioinformatics pipeline describes 390 putative, novel inhibitory receptors, to facilitate targeted therapeutic strategies for diverse immune cell types in cancer therapy.

In mammals, autophagosome formation, a central event in autophagy, is initiated by the ULK complex comprising ULK1/2, FIP200, ATG13, and ATG101. However, the structural basis and mechanism of the ULK ...

Aggregation of mutant forms of Huntingtin is the underlying feature of neurodegeneration observed in Huntington's disorder. In addition to neurons, cellular processes in non-neuronal cell types are ...

The advent of large-scale sequencing in both development and disease has identified large numbers of candidate genes that may be linked to important phenotypes. Validating the function of these ...