Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...

The link between gut microbiome and eating behaviours, especially palatable food intake, is a growing focus of scientific ...

Objective Neutralising pro-inflammatory interleukin-6 (IL-6) may effectively treat Crohn’s disease (CD). Effects of PF-04236921, an anti-IL-6 antibody, in adults with CD are reported. Results 247 ...

It is now widely recognised that host–microbiome interactions play a major role in the control of energy metabolism and ...

Correspondence to Brian B Scott, Department of Medicine, Lincoln County Hospital, Lincoln LN2 5QY, UK; drbbscott{at}aol.com Iron deficiency anaemia (IDA) occurs in 2–5% of adult men and postmenopausal ...

Objective Pancreatic ductal adenocarcinoma (PDAC) shows a remarkable predilection for liver metastasis. Pro-oncogenic secretome delivery and trafficking via exosomes are crucial for pre-metastatic ...

Objective Delayed second dose SARS-CoV-2 vaccination trades maximal effectiveness for a lower level of immunity across more of the population. We investigated whether patients with inflammatory bowel ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

Correspondence to Dr Ka Shing Cheung, Department of Medicine, The University of Hong Kong, Hong Kong 999077, Hong Kong; cks634{at}hku.hk; Prof Wai-Kay Seto; wkseto{at}hku.hk Objective Whether varying ...

Objective The microbiome contributes to the pathogenesis of inflammatory bowel disease (IBD) but the relative contribution of different lifestyle and environmental factors to the compositional ...

Crohn disease is a chronic condition characterised by intestinal inflammation and progressive bowel damage associated with impaired functioning. In rheumatoid arthritis, which shares some common ...